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PGT-P (Polygenic Risk Score)

Genetic Compass for Healthy Generations

PGT-P (Polygenic Preimplantation Genetic Testing) in IVF

Risk Assessment for Complex Diseases

While conventional PGT methods focus on detecting chromosomal abnormalities (PGT-A) or single-gene disorders (PGT-M) in embryos, PGT-P extends beyond these approaches by assessing genetic susceptibility to multifactorial (complex) diseases that may develop throughout an individual’s lifetime using Polygenic Risk Scores (PRS).

Conditions such as cardiovascular disease, diabetes, hypertension, obesity, and certain types of cancer are not caused by a single gene. Instead, they result from the combined effects of hundreds or even thousands of genetic variants together with environmental factors. PGT-P evaluates an embryo’s genetic predisposition to these conditions and generates a comprehensive genetic risk profile based on PRS.

This approach supports the selection of the embryo with the lowest predicted genetic risk for chronic and complex diseases, helping provide the best possible start to life.

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