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Pediatric Acute Lymphoblastic Leukemia (ALL) Relapse Panel

Pediatric Acute Lymphoblastic Leukemia (ALL) – Relapse Panel is a test panel designed to investigate specific genetic and chromosomal alterations in leukemia cells when the disease returns after treatment. ALL relapse refers to the recurrence of the disease after it has been brought under control with treatment. Alterations involving genes such as IKZF1, CRLF2, MYC, and TP53, as well as specific chromosomal abnormalities, may be important for understanding the biological characteristics of the disease and supporting clinical evaluation. The panel analyzes these alterations using the FISH method.

 

Genetic AlterationMethodSample Type
7p12.2  IKZF1FISHBone Marrow / Heparinized Blood
Xp22.3  CRLF2FISHBone Marrow / Heparinized Blood
FIPIL1-PDGFRA – CHIC2 (4q12)FISHBone Marrow / Heparinized Blood
8q24.12 – q24.13 C MYCFISHBone Marrow / Heparinized Blood
9p21 del  P16/CEP9FISHBone Marrow / Heparinized Blood
t(9;22)(q34;q11.2)FISHBone Marrow / Heparinized Blood
11q22.3 del  ATMFISHBone Marrow / Heparinized Blood
11q23 FISHBone Marrow / Heparinized Blood
t(12;21)(p13;q22) FISHBone Marrow / Heparinized Blood
14q32 del IgHFISHBone Marrow / Heparinized Blood
del 17p13.1 (p53) FISHBone Marrow / Heparinized Blood
19p13 E2AFISHBone Marrow / Heparinized Blood

 

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