
Pediatric Acute Lymphoblastic Leukemia (ALL) is a type of cancer that develops when immature forms of white blood cells called lymphocytes multiply uncontrollably in the bone marrow. It is the most common type of leukemia in childhood. The disease can interfere with normal blood cell production, leading to symptoms such as anemia, increased susceptibility to infections, and bleeding. Certain chromosomal translocations and genetic alterations play an important role in the development and classification of the disease. The Pediatric ALL Panel investigates these alterations using FISH, RT-PCR, and PCR methods.
| Genetic Alteration | Method | Sample Type |
|---|---|---|
| t(9;22)(q34;q11.2) | FISH | Bone Marrow / Heparinized Blood |
| t(9;22) | RT-PCR | Bone Marrow / EDTA Blood |
| t(12;21)(p13;q22) | FISH | Bone Marrow / Heparinized Blood |
| t(12;21) | RT-PCR | Bone Marrow / EDTA Blood |
| t(1;19)(q22;p13) | FISH | Bone Marrow / Heparinized Blood |
| t(1;19) | PCR | Bone Marrow / EDTA Blood |
| 11q23 | FISH | Bone Marrow / Heparinized Blood |
| t(8;14)(q24;q32) | FISH | Bone Marrow / Heparinized Blood |
| t(8;22), t(8;22) MYC | FISH | Bone Marrow / Heparinized Blood |
| t(4;11)(q21;q23) | FISH | Bone Marrow / Heparinized Blood |
| t(9;11)(p22;q23) | FISH | Bone Marrow / Heparinized Blood |
| t(11;19)(q23;p13) | FISH | Bone Marrow / Heparinized Blood |
19 Mayıs Mah. Çoruh Sok. No:32/1 Fulya, 34394 Şişli / Istanbul, Turkey
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