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Chronic Myeloid Leukemia (CML) Panel

Chronic Myeloid Leukemia (CML) is a type of blood cancer characterized by the uncontrolled proliferation of myeloid cells in the bone marrow. The disease is most commonly associated with the t(9;22) translocation, which leads to the formation of the Philadelphia chromosome and the resulting BCR::ABL1 fusion gene. The Chronic Myeloid Leukemia (CML) Panel investigates this translocation and certain other chromosomal abnormalities using FISH and RT-PCR methods.

 

Genetic AlterationsMethodSample Type
t(9;22)(q34;q11.2)FISHBone Marrow / Heparinized Blood
t(9;22)RT-PCRBone Marrow / EDTA Blood
inv(16)(p13q22)FISHBone Marrow / Heparinized Blood
inv(16)RT-PCRBone Marrow / EDTA Blood
5q31 DeletionFISHBone Marrow / Heparinized Blood
7q31 DeletionFISHBone Marrow / Heparinized Blood
Trisomy / Monosomy 8FISHBone Marrow / Heparinized Blood

 

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