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Pediatric Acute Lymphoblastic Leukemia (ALL) Panel

Pediatric Acute Lymphoblastic Leukemia (ALL) is a type of cancer that develops when immature forms of white blood cells called lymphocytes multiply uncontrollably in the bone marrow. It is the most common type of leukemia in childhood. The disease can interfere with normal blood cell production, leading to symptoms such as anemia, increased susceptibility to infections, and bleeding. Certain chromosomal translocations and genetic alterations play an important role in the development and classification of the disease. The Pediatric ALL Panel investigates these alterations using FISH, RT-PCR, and PCR methods.

 

Genetic AlterationMethodSample Type
t(9;22)(q34;q11.2)FISHBone Marrow / Heparinized Blood
t(9;22)RT-PCRBone Marrow / EDTA Blood
t(12;21)(p13;q22)FISHBone Marrow / Heparinized Blood
t(12;21)RT-PCRBone Marrow / EDTA Blood
t(1;19)(q22;p13)FISHBone Marrow / Heparinized Blood
t(1;19)PCRBone Marrow / EDTA Blood
11q23FISHBone Marrow / Heparinized Blood
t(8;14)(q24;q32)FISHBone Marrow / Heparinized Blood
t(8;22), t(8;22) MYCFISHBone Marrow / Heparinized Blood
t(4;11)(q21;q23)FISHBone Marrow / Heparinized Blood
t(9;11)(p22;q23)FISHBone Marrow / Heparinized Blood
t(11;19)(q23;p13)FISHBone Marrow / Heparinized Blood

 

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