
Chronic Myeloid Leukemia (CML) is a type of blood cancer characterized by the uncontrolled proliferation of myeloid cells in the bone marrow. The disease is most commonly associated with the t(9;22) translocation, which leads to the formation of the Philadelphia chromosome and the resulting BCR::ABL1 fusion gene. The Chronic Myeloid Leukemia (CML) Panel investigates this translocation and certain other chromosomal abnormalities using FISH and RT-PCR methods.
| Genetic Alterations | Method | Sample Type |
| t(9;22)(q34;q11.2) | FISH | Bone Marrow / Heparinized Blood |
| t(9;22) | RT-PCR | Bone Marrow / EDTA Blood |
| inv(16)(p13q22) | FISH | Bone Marrow / Heparinized Blood |
| inv(16) | RT-PCR | Bone Marrow / EDTA Blood |
| 5q31 Deletion | FISH | Bone Marrow / Heparinized Blood |
| 7q31 Deletion | FISH | Bone Marrow / Heparinized Blood |
| Trisomy / Monosomy 8 | FISH | Bone Marrow / Heparinized Blood |
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