{"id":12684,"date":"2026-02-03T14:23:14","date_gmt":"2026-02-03T11:23:14","guid":{"rendered":"https:\/\/nesiller.com\/preimplantation-genetic-diagnosis-pgt\/"},"modified":"2026-10-26T10:27:00","modified_gmt":"2026-10-26T07:27:00","slug":"preimplantation-genetic-diagnosis-pgd","status":"publish","type":"page","link":"https:\/\/nesiller.com\/en\/preimplantation-genetic-diagnosis-pgd\/","title":{"rendered":"Preimplantation Genetic Diagnosis (PGD)"},"content":{"rendered":"\t\t
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Preimplantation Genetic Diagnosis (PGT) <\/div>\t\t\t\t<\/div>\n\t\t\t\t
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Preimplantation Genetic Testing (PGT)<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
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Genetically select the most accurate embryo<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What Is Preimplantation Genetic Testing (PGT)?<\/strong><\/h2>

Preimplantation Genetic Testing (PGT) is a genetic testing method used to examine embryos created through in vitro fertilization (IVF) for specific genetic and chromosomal characteristics before they are transferred into the uterus. Preimplantation genetic testing helps identify certain genetic changes or chromosomal abnormalities in embryos, supporting embryo selection based on the test results. This approach can support IVF treatment planning in cases involving known risks of inherited genetic disorders or specific chromosomal abnormalities.<\/p>

During the IVF process, embryos begin developing following fertilization and are monitored in the laboratory. Typically, on day 5 or 6 after fertilization, embryos that have reached the blastocyst stage undergo trophectoderm biopsy to collect a small sample of cells. The trophectoderm is the outer cell layer of the embryo that contributes to the formation of the placenta during subsequent development. The collected samples are analyzed using methods appropriate to the scope of the planned genetic test.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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How Does the Preimplantation Genetic Testing Process Work?<\/strong><\/h2>

Preimplantation Genetic Testing (PGT) is performed as part of the in vitro fertilization (IVF) process and involves several stages, including embryo development, biopsy, genetic analysis, and evaluation of the results.<\/p>

1. IVF Treatment and Fertilization<\/strong><\/h3>

During treatment, the ovaries are stimulated in a controlled manner, and mature eggs are collected. The eggs are fertilized with sperm in the laboratory to initiate embryo development. The embryos are monitored in the laboratory throughout the subsequent stages.<\/p>

2. Blastocyst Biopsy<\/strong><\/h3>

Typically, on day 5 or 6 after fertilization, embryos that have reached the blastocyst stage undergo trophectoderm biopsy to collect a sample of cells for preimplantation genetic testing. The biopsy procedure is performed with consideration of the embryo’s developmental characteristics and laboratory protocols.<\/p>

3. Genetic Analysis<\/strong><\/h3>

The genetic material obtained from the biopsy sample is analyzed using methods appropriate to the purpose of the planned test. Molecular technologies such as Next-Generation Sequencing (NGS) may be used to assess specific genetic and chromosomal changes, depending on the scope of the test.<\/p>

4. Evaluation of Results and Embryo Transfer<\/strong><\/h3>

The genetic analysis results help evaluate embryos with respect to the characteristics examined by the test. In planning embryo transfer, genetic findings are considered alongside embryo development and clinical assessment. The decision to proceed with transfer is made based on the evaluation of the relevant healthcare professionals.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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PGT Indications:<\/b><\/h2>

According to ASRM<\/b> and <\/span>ESHRE <\/b>guidelines, PGT is recommended in the following situations:<\/span><\/p>