{"id":12663,"date":"2026-02-10T19:57:13","date_gmt":"2026-02-10T16:57:13","guid":{"rendered":"https:\/\/nesiller.com\/altera-comprehensive-genomic-profiling-whole-exome-transcriptome\/"},"modified":"2026-10-20T14:15:50","modified_gmt":"2026-10-20T11:15:50","slug":"altera-comprehensive-genomic-profiling-whole-exome-transcriptome","status":"publish","type":"page","link":"https:\/\/nesiller.com\/en\/oncology\/altera-comprehensive-genomic-profiling-whole-exome-transcriptome\/","title":{"rendered":"Altera\u2122 Comprehensive Genomic Profiling (Whole Exome + Transcriptome)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"12663\" class=\"elementor elementor-12663 elementor-10917\" data-elementor-post-type=\"page\">\n\t\t\t\t<div data-ekitparallax=\"{&quot;ekit_section_parallax_bg&quot;:&quot;yes&quot;,&quot;ekit_section_parallax_bg_speed&quot;:0.5,&quot;elementor_lazy_load&quot;:&quot;1&quot;}\" class=\"elementor-element elementor-element-227128e e-flex e-con-boxed e-con e-parent\" data-id=\"227128e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-bbf6a96 e-con-full e-flex e-con e-child\" data-id=\"bbf6a96\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6860096 section-title at-heading-animation at-animation-heading-none elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"6860096\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/nesiller.com\/en\/oncology\/\">Oncology<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b662ac elementor-widget elementor-widget-heading\" data-id=\"0b662ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Altera\u2122 Whole Exome (WES) + Transcriptome (WTS)\n\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17680f7 at-heading-animation at-animation-heading-style-2 elementor-widget elementor-widget-heading\" data-id=\"17680f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Comprehensive Genomic Profiling<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4d45435 e-con-full e-flex e-con e-child\" data-id=\"4d45435\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element- elementor-widget__width-auto elementor-widget elementor-widget-button\" data-id=\"\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/nesiller.com\/wp-content\/uploads\/2026\/08\/altera-brochure-1.pdf\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Test brochure<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a66f60d elementor-widget__width-auto elementor-widget elementor-widget-button\" data-id=\"a66f60d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/nesiller.com\/wp-content\/uploads\/2026\/08\/Altera-Breast_Revised.pdf\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Sample Report<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-29319d5 e-flex e-con-boxed e-con e-parent\" data-id=\"29319d5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-315b981 elementor-widget elementor-widget-text-editor\" data-id=\"315b981\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.natera.com\/oncology\/altera\/\" target=\"_blank\" rel=\"noopener\">Altera<\/a>\u2122 combines Whole Exome Sequencing (WES) and Whole Transcriptome Sequencing (WTS) to enable deeper understanding of each cancer\u2019s unique genomic signature. It identifies clinically relevant biomarkers that support the selection of targeted therapies and immunotherapies, while also helping match patients to appropriate clinical trials.<\/span><\/p><p>Altera\u2122 is performed at <strong>Natera<\/strong>\u2019s Clinical Laboratory Improvement Amendments (<strong>CLIA<\/strong>) certified laboratories in the <strong>United States<\/strong>.<\/p><p><b>Technical Features<\/b><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Whole Exome DNA Sequencing (WES)<\/b><b><br><\/b><span style=\"font-weight: 400;\">Analyzes approximately 20,000 genes to identify genomic alterations associated with targeted and immunotherapy options, including SNVs, indels, and CNAs. Also evaluates MSI and TMB status.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Whole Transcriptome RNA Sequencing (WTS)<\/b><b><br><\/b><span style=\"font-weight: 400;\">Extends analysis beyond the exome to detect structural rearrangements, clinically significant transcripts (such as AR-V7 and EGFR vIII), and fusions that may be missed by conventional panels (including NTRK 1\/2\/3).<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>IHC (Immunohistochemistry)<\/b><b><br><\/b><span style=\"font-weight: 400;\">Includes PD-L1 (22C3) and HER2 assessment to support personalized treatment strategy.<\/span><\/li><\/ul><p><b>Technical Specifications<\/b><\/p><table><tbody><tr><td><p><b>Feature<\/b><\/p><\/td><td><p><b>Details<\/b><\/p><\/td><\/tr><tr><td><p><b>Method<\/b><\/p><\/td><td><p><span style=\"font-weight: 400;\">WES (DNA) + WTS (RNA) + IHC<\/span><\/p><\/td><\/tr><tr><td><p><b>Coverage<\/b><\/p><\/td><td><p><span style=\"font-weight: 400;\">~20,000 Genes, MSI, TMB, PD-L1 (22C3), HER2, Fusions, and Drug Sensitivity<\/span><\/p><\/td><\/tr><tr><td><p><b>Sample Type<\/b><\/p><\/td><td><p><span style=\"font-weight: 400;\">FFPE Tumor Tissue + EDTA Blood<\/span><\/p><\/td><\/tr><tr><td><p><b>Clinical Utility<\/b><\/p><\/td><td><p><span style=\"font-weight: 400;\">Targeted therapy selection<\/span><\/p><p><span style=\"font-weight: 400;\">Immunotherapy eligibility<\/span><\/p><p><span style=\"font-weight: 400;\">Clinical trial matching<\/span><\/p><\/td><\/tr><tr><td><p><b>Turnaround Time<\/b><\/p><\/td><td><p><span style=\"font-weight: 400;\">3 Weeks<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><span style=\"font-weight: 400;\"><br>While <\/span><b>Altera\u2122<\/b><span style=\"font-weight: 400;\"> determines the optimal treatment strategy, <\/span><b><span style=\"text-decoration: underline;\"><a href=\"https:\/\/nesiller.com\/en\/oncology\/signatera-minimal-residual-disease-mrd\/\">Signatera<\/a><\/span>\u2122<\/b><span style=\"font-weight: 400;\"> enables molecular recurrence monitoring. This dual approach ensures <\/span><b>tissue conservation<\/b><span style=\"font-weight: 400;\"> by utilizing a single tumor sample. It optimizes the therapeutic process and provides the opportunity for long-term personalized monitoring.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Oncology Altera\u2122 Whole Exome (WES) + Transcriptome (WTS) Comprehensive Genomic Profiling Test [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":12725,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-12663","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/comments?post=12663"}],"version-history":[{"count":45,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12663\/revisions"}],"predecessor-version":[{"id":21605,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12663\/revisions\/21605"}],"up":[{"embeddable":true,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12725"}],"wp:attachment":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/media?parent=12663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}