{"id":12652,"date":"2026-02-11T15:00:14","date_gmt":"2026-02-11T12:00:14","guid":{"rendered":"https:\/\/nesiller.com\/intelligene-whole-exome-sequencing-wes\/"},"modified":"2026-10-11T09:32:46","modified_gmt":"2026-10-11T06:32:46","slug":"intelligene-whole-exome-sequencing-wes","status":"publish","type":"page","link":"https:\/\/nesiller.com\/en\/intelligene-whole-exome-sequencing-wes\/","title":{"rendered":"IntelliGene \u2013 Whole Exome Sequencing (WES)"},"content":{"rendered":"\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t
\n\t\t\t\t
\n\t\t\t\t\t
Genomic Tests<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t

IntelliGene \u2013 Whole Exome Sequencing (WES)<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tTest brochure<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

With WES, approximately 20,000 protein-coding genes in DNA are analyzed using Next-Generation Sequencing (NGS). This test identifies genetic variants that may cause disease, affect quality of life, or remain asymptomatic while being passed on to future generations.<\/span><\/p>

It is particularly recommended for cases involving unexplained developmental delay, neurological findings, congenital anomalies, recurrent pregnancy loss, or a family history of genetic disease. WES supports identification of the genetic cause and helps guide appropriate treatment or follow-up strategies.<\/span><\/p>

What Is the Exome and Why Is It Important?<\/b><\/p>

Genes consist of exons and introns. Exons are the \u201ccoding\u201d regions that contain instructions for protein production. The exome represents only about 1\u20132% of the genome, yet the majority of pathogenic variants are located in these regions. Introns are non-coding regions between exons.<\/span><\/p>

Clinical Indications for WES<\/b><\/p>

  • Neurodevelopmental and metabolic disorders in newborns and early childhood<\/span><\/p><\/li>

  • Clinical presentations suggestive of genetic etiology but unexplained by standard testing<\/span><\/p><\/li>

  • Adult patients with inconclusive standard genetic results<\/span><\/p><\/li>

  • Rare, complex, diagnostically challenging developmental or functional disorders<\/span><\/p><\/li>

  • Risk assessment for familial disease predisposition<\/span><\/p><\/li>

  • Personalized nutrition planning based on nutrigenomic insights<\/span><\/p><\/li>

  • Personalized treatment planning based on pharmacogenomic data (drug response and adverse effect profiling)<\/span>
    <\/span><\/p><\/li><\/ul>

    Technical Specifications<\/b><\/p>

    Feature (\u00d6zellik)<\/b><\/p><\/td>

    Details (Detaylar)<\/b><\/p><\/td><\/tr>

    Method<\/b><\/p><\/td>

    NGS (Next-Generation Sequencing)<\/span><\/p><\/td><\/tr>

    Coverage<\/b><\/p><\/td>

    ~20,000 Genes (SNV, Indel, CNV)<\/span><\/p><\/td><\/tr>

    Sample Requirements<\/b><\/p><\/td>

    EDTA Blood<\/span>Amniotic Fluid<\/span>CVS (Chorionic Villus Sampling)<\/span>Buccal Swab<\/span><\/p><\/td><\/tr>

    Turnaround Time<\/b><\/p><\/td>

    4 \u2013 6 Weeks<\/span><\/p><\/td><\/tr><\/tbody><\/table>


    *For a detailed sample collection, please contact our team.<\/span><\/p>

    Nesiller Genetics reports WES results by integrating family history, clinical data, and bioinformatic databases.<\/span><\/i><\/p>

    Genetic Counseling<\/b><\/p>

    • Pre-test counseling<\/span><\/p><\/li>

    • Clinical integration of results and family guidance<\/span><\/p><\/li>

    • Follow-up consultation<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

      Genomic Tests IntelliGene \u2013 Whole Exome Sequencing (WES) Test brochure With WES, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-12652","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/comments?post=12652"}],"version-history":[{"count":18,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12652\/revisions"}],"predecessor-version":[{"id":20787,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12652\/revisions\/20787"}],"wp:attachment":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/media?parent=12652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}