{"id":12623,"date":"2026-02-12T08:05:38","date_gmt":"2026-02-12T05:05:38","guid":{"rendered":"https:\/\/nesiller.com\/thalassemia\/"},"modified":"2026-10-03T18:35:30","modified_gmt":"2026-10-03T15:35:30","slug":"thalassemia","status":"publish","type":"page","link":"https:\/\/nesiller.com\/en\/carrier-screening\/thalassemia\/","title":{"rendered":"Thalassemia"},"content":{"rendered":"\t\t
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Carrier Screening and Reproductive Genetics<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t
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Thalassemia <\/h1>\t\t\t\t<\/div>\n\t\t\t\t
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The First Step in Family Planning<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Alpha Thalassemia<\/strong> is an inherited blood disorder that affects hemoglobin, the protein in red blood cells responsible for transporting oxygen throughout the body. Hemoglobin consists of two different protein chains: alpha and beta.<\/p>

Alpha Thalassemia is caused by genetic variants in the HBA1<\/strong> and HBA2<\/strong> genes, which work together to produce the alpha-globin protein. Depending on the number of affected genes, the clinical presentation may range from mild anemia to the most severe form, hydrops fetalis<\/strong>, which is often fatal before birth.<\/p>
Feature\u00a0<\/b><\/td>Details<\/b><\/td><\/tr>
Method<\/b><\/td>NGS \/ MLPA<\/span><\/td><\/tr>
Coverage<\/b><\/td>HBA1, HBA2 genes
<\/span><\/i><\/td><\/tr>
Sample Requirement\u00a0<\/b><\/td>

Blood (EDTA Tube)<\/span><\/p>

Amniotic Fluid\u00a0<\/span><\/p>

CVS<\/span><\/p><\/td><\/tr>

Turnaround Time (TAT)\u00a0<\/b><\/td>15 days<\/span><\/td><\/tr><\/tbody><\/table>


Beta Thalassemia<\/strong> is an inherited blood disorder that affects the body’s ability to produce hemoglobin. Variants in the HBB<\/strong> gene reduce or prevent the production of beta-globin, resulting in a decreased number of healthy red blood cells and leading to anemia.<\/p>

Individuals carrying a single altered HBB<\/strong> gene typically have a mild form of the condition, whereas the severe form \u00a0(Mediterranean anemia<\/strong>) can cause chronic anemia, serious organ complications, and a lifelong need for regular blood transfusions.<\/p>

The severity of the disease depends on the inheritance pattern of the mutated HBB<\/strong> gene:<\/p>

  • Inherited from one parent:<\/strong> Carrier status or a mild form (beta thalassemia minor<\/strong>)<\/li>
  • Inherited from both parents:<\/strong> Severe form (beta thalassemia major<\/strong>)<\/li><\/ul>

    Genetic testing can determine your carrier status or confirm a diagnosis of beta thalassemia.<\/p>
    Feature\u00a0<\/b><\/td>Details<\/b><\/td><\/tr>
    Method<\/b><\/td>NGS \/ MLPA<\/span><\/td><\/tr>
    Coverage<\/b><\/td>HBB gene
    <\/span><\/i><\/td><\/tr>
    Sample Requirement\u00a0<\/b><\/td>

    Blood (EDTA Tube)<\/span><\/p>

    Amniotic Fluid\u00a0<\/span><\/p>

    CVS<\/span><\/p><\/td><\/tr>

    Turnaround Time (TAT)\u00a0<\/b><\/td>15 days<\/span><\/td><\/tr><\/tbody><\/table>

    *For a detailed sample collection, please contact our team.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Carrier Screening and Reproductive Genetics Thalassemia The First Step in Family Planning […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":12705,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-12623","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/comments?post=12623"}],"version-history":[{"count":22,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12623\/revisions"}],"predecessor-version":[{"id":20815,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12623\/revisions\/20815"}],"up":[{"embeddable":true,"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/pages\/12705"}],"wp:attachment":[{"href":"https:\/\/nesiller.com\/en\/wp-json\/wp\/v2\/media?parent=12623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}