[kswr_heading head_title_color=”{“type“:“color“,“color1“:“#5f2e89“,“color2“:“#333“,“direction“:“to left“}” head_subtitle_color=”#333333″ head_title=”WHO CAN BENEFIT FROM PGD? (preimplantation genetic diagnosis)” head_title_fsize=”font-size:22px;” head_title_fstyle=”font-family:Ubuntu;font-weight:600;” head_subtitle_fsize=”font-size:14px;” head_subtitle_fstyle=”font-family:Inherit;font-weight:inherit;” head_title_margins=”margin-top:0px;margin-bottom:0px;” head_subtitle_margins=”margin-top:0px;margin-bottom:0px;”][/kswr_heading]

Couples with a genetic disease linked to X chromosome in their families : When the mother is a carrier, it means she has one healthy and one diseased X chromosome. Daughters get one X chromosome from mother and one from father and with 50% possibility they become healthy individuals or they become disease carriers. Sons get only one X chromosome from mother and a Y chromosome from father in return. For this reason, possibility of being diseased for sons is 50%. When father is diseased, sons become healthy individuals yet all the daughters become carriers. Several diseases such as myopathies, hemopholia, Fragile X are inherited by X chromosome.

Couples carrying an autosomal recessive disease : In a case that parents carry an autosomal ressesive disase, newborns’ possibility of being diseased are 25%. Consanguineous marriages increase the incidences by bunching diseased genes together. Examples of autosomal ressesive diseases are; beta thalassemia, cystic fibrosis,  spinal muscular atrophy, fanconi anemia, Tay-Sachs disease.

Couples carrying an autosomal dominant disease : If mother or father has an autosomal dominant disease like Huntington, polycystic kidney disease, possibility of newborns to be diseased is 50%.

Couples carrying structural chromosome abnormalities : Mother’s or father’s chromosome abnormalities such as translocation, inversion or deletion cause recurrent abortus, failures in IVF applications, physical and/or cognitive problems at newborns.

HLA-Matched siblings : HLA-matched donor is necessary in diseases like; thalassemia, leucemia which requires stem cell or bond marrow transplantation. With PGD, for a HLA-matched sibling, embryo selection can be made.

Elderly mothers : As the maternal age advances, risk of having babies with abnormal number of chromosomes rises. In elder ages, during ovogenesis cellular division does not occur correctly so embryos may have less or more chromosomes. Most common aneuploidies are; Trisomy 21 which causes Down Syndrome. When the age of giving birth is 35, possibility of having a baby with Down Syndrome is 1/350, it rises to 1/200 when maternal age reaches 40.

Families with aneuploidy history (Down, Edward’s, Patau Syndrome) : Aneuploidy risk is higher for children of couples who have a previous pregnancy with aneuploidy or baby with aneuploidy.

Recurrent miscarriages and recurrent IVF failure cases : For couples experiencing recurrent miscarriages, aneuploidy in fetus is seen at 50-80% of all cases. Aneuploidy rates of these couples are higher than others according to PGD results.

Male infertility : In male infertility cases, chromosomal abnormality rates are higher. Sperms that used in IVF cause transfer of chromosomal abnormality to embryo and cause recurrent IVF failures, even aneuploidy at child.

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